About this product

Dosage and Administration
Adults and the elderly: One drop applied topically to the eye as required.
Children: At the discretion of the physician.
Each Minims Prednisolone Eye Drops unit should be discarded after a single use.

Contraindications
Patients with hypersensitivity to any of the components of the preparation; presence of viral, fungal, tuberculous or
other bacterial infection; in children, long-term, continuous topical corticosteroid therapy should be avoided due to
possible adrenal suppression; glaucoma.

Precautions
For topical ophthalmic use only. Not for injection. Care should be taken to ensure that the eye is not infected before
Minims Prednisolone Eye Drops is used. Corticosteroids may reduce resistance to and aid in the establishment of
bacterial, viral, or fungal infections and mask the clinical signs of infection, preventing recognition of ineffectiveness of
the antibiotic, or may suppress hypersensitivity reactions to substances in the product. Steroid medication in the
treatment of patients with a history of herpes simplex keratitis requires great caution; frequent slit microscopy is
mandatory. Prolonged application of corticosteroid preparations to the eye has caused increased intraocular
pressure. Various ocular diseases and long-term use of topical corticosteroids have been known to cause corneal and
scleral thinning. Use of topical corticosteroids in the presence of thin corneal or scleral tissues may lead to perforation.
Visual disturbance may be reported; if a patient presents with blurred vision or other visual disturbances, the patient
should be considered for referral to an ophthalmologist.

Interactions
Corticosteroids are known to increase the effects of barbiturates, sedative hypnotics and tricyclic antidepressants and
decrease the effects of anticholinesterases, antiviral eye preparations and salicylates. Co-treatment with CYP3A
inhibitors, including cobicistat-containing products, is expected to increase the risk of systemic side-effects.

Pregnancy & Lactation
Topical administration of corticosteroids to pregnant animals can cause abnormalities of foetal development. Although
the relevance to humans has not been established, use of Minims Prednisolone Eye Drops during pregnancy should be
avoided. Systemically absorbed prednisolone is excreted in breast milk, therefore, use of Minims Prednisolone Eye
Drops in breastfeeding mothers is not recommended.

Ability to Drive & Use Machines
May cause blurred vision or visual disturbances. Patients should be advised not to drive or operate hazardous machinery
if they do not have clear vision.

Adverse Effects
Prolonged treatment with corticosteroids in high dosage is occasionally associated with cataract development. Other
ocular effects include transient ocular discomfort, posterior subcapsular cataracts, ocular hypertension or glaucoma,
defects in visual acuity and field of vision, optic nerve damage, decreased resistance to ocular infection, corneal epithelial
healing impairment, uveitis, mydriasis, ptosis and blurred vision. Following long term therapy, systemic effects are rarely
reported but possible following the use of Minims Prednisolone Eye Drops.

Storage
Store at 2°C to 8°C. Protect from light.